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Epic Test Code LAB192 Quinidine, Serum

Additional Codes

MML Code: QUIND

Useful For

Assessing and adjusting dosage for optimal therapeutic level

 

Assessing toxicity

Method Name

Kinetic Interaction of Microparticles in Solution (KIMS)

Reporting Name

Quinidine, S

Specimen Type

Serum Red


Specimen Required


Container/Tube: Red top

Specimen Volume: 0.5 mL

Collection Instructions: Red-top tubes should be centrifuged and aliquoted within 2 hours of collection.


Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 14 days
  Frozen  28 days
  Ambient  14 days

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

NA

Icterus

NA

Other

Serum gel tube

Clinical Information

Quinidine is indicated for atrial fibrillation and flutter, and life-threatening ventricular arrhythmia. Optimal serum concentrations are in the range of 2.0 to 5.0 mcg/mL, with toxicity apparent at levels ≥6.0 mcg/mL. Symptoms of toxicity (cinchonism) include tinnitus, light-headedness, premature ventricular contractions, and atrioventricular block. Gastrointestinal distress is a frequent side effect, which becomes more severe and is associated with nausea and vomiting at higher drug concentrations.

 

The half-life of quinidine is 6 to 8 hours, and the drug lacks any significant active metabolites. Physiologic processes that generally reduce hepatic metabolism and renal clearance increase serum quinidine levels, while comedication with cytochrome p450 (CYP) enzyme inducers enhances clearance and results in lower blood concentrations.

Reference Values

Therapeutic: 2.0-5.0 mcg/mL

Critical value: ≥6.0 mcg/mL

Interpretation

Optimal response to quinidine occurs when the serum level is between 2.0 to 5.0 mcg/mL.

Cautions

No significant cautionary statements.

Day(s) and Time(s) Performed

Monday through Sunday; Continuously

Analytic Time

Same day/1 day

Specimen Retention Time

1 week

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

80194

NY State Approved

Yes