Leukoreduced Platelet Pheresis

1. Platelet count is less than 5,000 - 10,000/ml, or less than 50,000/ml with active bleeding in a perioperative patient.
2. Functional platelet disorders with counts greater than 50,000/ml
3. Thrombocytopenic DIC
   • Note: Assessment of clinical response to platelet transfusion with one and twenty four hour post transfusion platelet counts is recommended.

1. Limited supply stocked inhouse.
2. Routine Deliveries: Tuesdays and Fridays before noon, Monday and Wednesday by 6PM
3. Minimum 1 hour/Maximum 5 hour TAT if supply not available in house.
4. Equivalent of 6-8 random donor platelet concentrates with exposure to only one donor.

Irradiated Leukoreduced Platelet Pheresis

1. By recommendation from the Hematology/Oncology section for:
   1. Immunocompromised patients at risk of GVHD (Graft vs Host Disease).
   2. Bone marrow transplant recipients and congenital immunodeficiency syndrome.
   3. Leukemia and lymphoma patients.

1. Limited supply stocked inhouse.
2. Routine Deliveries: Tuesdays and Fridays before noon, Monday and Wednesday by 6PM
3. Minimum 1 hour/Maximum 5 hour TAT if supply not available in house.
4. Equivalent of 6-8 random donor platelet concentrates with exposure to only one donor.

CMV Negative Irradiated Leukoreduced Platelet Pheresis

1. By recommendation from the Hematology/Oncology sectionfor:
   1. Immunocompromised patients at risk of developing GVHD (Graft vs Host Disease) or Cytomegalovirus. 
2. Transplant Candidates

1. Limited supply  stocked inhouse.
2. Routine Deliveries: Tuesdays and Fridays before noon, Monday and Wednesday by 6PM
3. Minimum 1 hour/Maximum 5 hour TAT if supply not available in house.
4. Only CMV seronegative patients require CMV negative products.  Determination of patient's CMV status is recommended.