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Platelet Function Test Information

Platelet Function Test

Note: Many drugs inhibit platelet function.  Unless the aim of testing is to demonstrate drug-induced inhibition, patients should be drug free prior to testing

 

 

Drugs That Inhibit Platelet Aggregation

 

Aminopyrine (Pyramidon)
Amitriptyline
Antruane (Sulfinpyrazone)
Aspirin
Atromide (Clofibrate)
Chloroquine
Chlorpromazine
Cyprohepatadine
Dextran

Dextropropoxyphene (Doloxene)
Dipyridamole (Persantine)
Furosemide (Lasix)
Glycerol-guiacolate
Heparin
Ibufenac (Dytransin)
Ibuprofen (Motrin)
Indomethacin (Indocin)
Imipramine

Maclofenamic acid
Mefamic acid (Ponstan)
Nitrofurantoin (Furadantin)
Paracetamol
Phenothiazines
Phenylbutazone
Promethazine
Pyrinolcarbamate
Sulfinpyrazone

Alpha-antagonist
Adrenergic blocking agent s
Adenosine
Aminophylline
Antihistamines
B-blocker
Black tree fungus

Cephalosporins
Clofibrate
Corticosteroids
Cyclic AMP
EDTA
Ethanol
Garlic

Local anaesthetics (procaine)
Non-steroid anti-inflammatory drugs
Prostaglandin E
Prostanoids
Sulphydril inhibitor
Tricyclic antidepressants
Volatile general anesthetics
 

 

Prescription Drugs That Contain Aspirin

Acetabar
Acetasem
Aidant with Dovers Powder
Allylgesic
Allylgesic with ergotamine
Alprine
Amsodyne
Amytal with ASA
Anexsia-D

APAC
APC with codeine
APC with gelsemium
Aphophen
ASA compound with codeine
Ascodeen-30
Ascriptin with codeine
Aspadine tab
Asphac-G

Asphac-G with codeine
Aspirin compound with Dover’s Powder
Aspirin-Pb tab
Aspirin-secobarbital Supprettes No. 1, 2, 3 & 4
Aspodyne with codeine
Axotal

Brogesic
Bufabar

Buff-a-Comp
Buffadyne-A-S Tab

  

Causalin
Cephalgesic
Clistanal
Codasa tab

Colrex Compound
Coralsone modified
Cordex

Cordex forte
Cordex Buffered
Cordex Forte Buffered

Daprisal
Darvon with ASA
Darvon-N with ASA
Darvon compound 32 & 65
Darvo-Tran
Dasin caps

Dasin-CS
Dasin ¼ Strength
Decagesic
Delenar
Derfort
Derfule

Dolene compound 65
Doloral
Dorodol
Drinacet
Drocogesic No. 3
Duopac

Edrisal
Empiral

Empiral Compound with Codeine
Empirazil-C

Epragen
Equagesic

Fiorinal

Fiorinal with codeine N 1, 2 &3

  

Gelsodyne

Grillodyne

  

Hasemal CT

    

I-PAC

    

Kryl

    

Lumasprin with hyoscyamus

    

Medadent

Medaprin

  

Nembu-Gesic

Nipirin

Norgesic

Paadon
PAC Compound tab
PAC compound with codeine
Palgesic
PC-65
Percobarb

Percobarb-Demi
Percodan
Phac tab
Phenaphen
Phenergan Compound Tabs

Pheno-Formasal
Polygesic
Predisal
Prolaire-B
Pyrroxate with codeine

Robaxisal

Robaxisal PH

  

Salibar Jr.
Salipral
Sarogesic
Sedagesic

Sedalgesic
Sigmagen
Stero-Darvon with ASA

Synalgos
Synalgos-DC
Synirin

Tetrex-APC with Bristamin

Trancogesic

Trancogesic

Zactirin

Zactirin Compound

  

 

Over-The-Counter Drugs That Contain Aspirin

             

ACA Caps & No. 2
ACD
Acetidine caps
Acetidine caps with codeine
Acetidine tabs with codeine
Acetonyl
Aidant
Aidant with gelsemium
Alka-Seltzer
Aluprin
Anacin
Anahist
Anexsia with codeine
Anodynos

Ansemco No. 1 & 2
Apamead
APC
APC with Demerol
Aphodyne
Arthra-Zene caps
ASA
ASA compound
Asalco No. 1 & 2
Ascaphen
Ascaphen compound
As-ca-phen
Ascriptin
Aspergum

Asphencaf
Asphyte
Aspirbar
Aspir-C
Aspireze
Aspirin (USP)
Aspirin aluminum
Aspirin children’s
Aspirin supprettes
Aspirjen Jr. Tabs
Aspir-phen
Aspivite caps
Aspodyne

Babylove
Ban-O-Pain
Bayer
Bayer Children’s
Bayer Timed-Release

B-C Headache Powder
Bristamin APC tabs
Buff-A
Buffacetin
Buffadyne

Buffadyne with barbiturates
B-C
Bufferin
Bufferin arthritis strength
Buffinol

Calurin
Cama Inlay
Capron
Cheracol caps
Cirin
Codempiral No. 2 & 3
Codesal No. 1 & 2

Coldate
Colrex
Congesprin
Cope
Coricidin
Coricidin D

Coricidin Demilets
Coricidin Medilets
Co-ryd
Counter Pain
Covangesic
Cyclopal and Aspirin

Dasikon
Derfort/ Derfule
Dolcin

Dolor
Dristan Tab

Duradyne
Duragesic

Ecotrin
Empirin

Emprazil
Excedrin

Excedrin PM

Fizrin

Formasal caps & tabs

4-way cold tabs

Henasphen
Histadyl & ASA compound

Hydrodyne Tabs

Hypan

Liquiprin

    

Marnal tab & cap
Measurin
Midol

Monacet compound caps
Monacet compound caps with
codein

Monacet compound tabs
Monacet compound tabs with
codeine

Nembudeine ¼, ½ & 1
Novahistine with APC

Navrad with ASA

Nuhist with APC

Opacedrin

Opasal

  

Pabirin
PAC with Cyclopal
Pedidyne
Pentagesic
Pentagill
Percodan-Demi
Persistan

Phenaphen with codeine
Phencasal
Phencaset improved
Phenodyne
Phensal
Pirseal
Ponodyne

Pyrasal
Pyrhist Cold
Pyrroxate
Pyrroxate caps
Pyrroxate caps with codeine
Pyrroxate tabs

Rhinex

Riona Caps

Ryd

Sal-Aceto
Sal-Fayne
Semaldyne caps
Sine-Aid

Sine-Off
Spirin Buffered
Stanback
St Joseph

St Joseph for Children
Supac
Super-Anahist

Tempogen Forte Tabs
Tempogen Tabs
Theylene APC Caps

Toloxidyne
Triaminicin

Trigesic
Triocin

Vanquish

  

             

Dietary-Supplement Drugs Interactions

DIETARY SUPPLEMENT

DRUG

ANTICIPATED EFFECT

Alfalfa

Warfarin

Herb contains vitamin K,
decreased drug efficacy

Angelica sinensis (dong quai)

Warfarin 

Herb contains coumarins, possible additive anticoagulation

Berberis vulagaris
(barberry)

Warfarin 

Herb contains berberine, antagonizes anticoagulation

Bromelains

Warfarin, Aspirin, Dipyridamole

Herb increase PT, Herb inhibits platelet aggregation

Garlic

Warfarin, Aspirin, Dipyridamole

Additive anticoagulant, Antiplatelet effects 

Ginko biloba

Warfarin, Aspirin, Dypyridamole

Additive anticoagulant, Antiplatelet effects, case reports of spontaneous bleeding from iris, Subdural hematoma

Hydrastis canadensis (goldenseal)

Warfarin

Herb contains berberine, Antagonizes anticoagulation

Mahonia aquifolium (Oregon grape)

Warfarin

Herb contains berberine, Antagonizes anticoagulation

Salviae multiorrhizae (cinnabar root)

Warfarin

Additive anticoagulant effect

Tanacetum parthenum (feverfew)

Warfarin, Aspirin, Diypyridamole

Additive anticoagulant, Antiplatelet effects 

Panax Ginseng

Warfarin

Herb is listed as having probable interaction with warfarin, but little documentation

 

Procedure Reference

  • Sweeney JD, Hoernig LA, Michnik A and Fitzpatrick JE: Whole Blood Aggregometry. Influence of Sample Collection and Delay in Study Performance on Test Results. Am J Clin Pathol 1989; 92:676-679.
  • Ingerman-Wojenski CM and Silver MJ: A Quick Method for Screening Platelet Dysfunctions Using the Whole Blood Lumi-Aggregometer. Thromb Hemostas 51-2 (154-156) 1984.
  • Podczasy JJ, Lee J, Vucenik I: Evaluation of Whole-Blood Lumiaggregation.Clin Appl. Thrombosis/Hemostasis, 3(3):190-195, 1997.
  • Sweeney JD, Hoernig LA and Fitzpatrick JE: Whole Blood Aggregation in von Willebrand Disease. Am J Hematol 32: 190-193 (1989).
  • Miller JL: Platelet-Type von Willebrand’s Disease. Thrombosis and Hemostasis Vol. 7, No. 4, 1985.
  • Sirridge, M: Laboratory Evaluation of the Bleeding Patient. Clinics in Laboratory Medicine, Vol. 4, No. 2, June 1984.
  • Challen A, Branch WJ, Cummings JH: Quantitation of Platelet Mass During Aggregation in the Electronic (Wellcome) Whole Blood Aggregometer.Journal of Pharmacological Methods 8, 1982.
  • Nieuwenhuis HK, Akkerman J-W N and Sixma JJ: Patients With a Prolonged Bleeding Time and Normal Aggregation Tests May Have Storage Pool Deficiency: Studies on One Hundred Six Patients. Blood 70-3 (620-623) 1987.
  • Riess H, Braun G, Brehm G and Hiller E.: Critical evaluation of platelet aggregation in human whole blood. Am J Clin Pathol, Vol. 85, No. 1, (50-56) 1986.
  • Gresele P, Zoja C, Deckmyn H, Arnout J, Vermylen J and Verstraete M: Dipyridamole Inhibits Platelet Aggregation in Whole Blood. Thromb Haemostas 50 (4) (852-856) 1983.
  • Mascelli MA, Worley S, Veriabo NJ, Lance ET, Mack S, Schaible T, Weisman HF and Jordan RE: Rapid Assessment of Platelet Function With a Modified Whole-Blood Aggregometer in Percutaneous Transluminal Coronary Angioplasty Patients Receiving Anti-GP Iib/IIIa Therapy. Circulation Vol. 96, No. 11, December 2, 1997.
  • Sweeney JD, Labuzetta JW, Fitzpatrick JE, The Effect of the Platelet Count on the Aggregation Response and Adenosine Triphosphate Release in an Impedance Lumi-Aggregometer. Am J Clin Pathol 1988; 89:655-659.
  • Sathiropas et al;Detection of Small Inhibitory Effects of Acetylsalicylic Acid (ASA) by Platelet Impedance Aggregometry in Whole Blood; Thrombosis Research 51; 55-62, 1988
  • Friend M, Vucenik I, Miller M. Research Pointers: Platelet responsiveness to aspirin patients with hyperlipidaemia. BMJ. 2003; 326(7380):82-8314.
  • Robert Poston, M.D. et al; Platelet Function Tests Predict Bleeding and Thrombotic Events After Off-Pump Coronary Bypass Grafting; Presented at the 4th annual Joint EACTS/ESTS Meeting, Leipzig, Germany, September 2004.
  • Dr. Joseph Sweeney, Director Dept of Hemostasis & Blood Bank, Miriam Hospital, Providence, RI. Established normal ranges. Data on file.