Epic Test Code CPAPD Conventional Smear-Diagnostic, Varies
Ordering Guidance
Laboratory approval prior to ordering cytology testing is required
Specimen submitted as endocervical curettage or endocervical brushing must be ordered as CYTNG/ Cytology Non-Gynecologic.
Necessary Information
1. An acceptable cytology request form must accompany specimen containers and include the following: Patient's name, medical record number, date of birth, sex, source (exact location and procedure used), date specimen was taken, name of ordering physician and pager number.
2. Submit any pertinent clinical information, including date of last menstrual period.
Specimen Required
Patient Preparation: For optimal interpretation, Papanicolaou smears should be collected near the middle of the menstrual cycle. No douching, lubricant use, or sexual intercourse for 24 hours prior to specimen collection.
Container/Tube: Slide
Specimen Volume: Circular scrape of cervical os
Collection Instructions:
1. Specimen containers must be labeled with a minimum of 2 unique identifiers (patient's name, and medical record number or date of birth). Containers should also be labeled with specimen source, and date collected.
2. Glass slides may be labeled with a single unique identifier, but 2 identifiers are preferred. If multiple slides are submitted, each slide must have proper identification. Glass slides should be identified with the patient's name and a second patient identifier that is also on the accompanying paperwork (ie, medical record number or date of birth)
3. Fix slides immediately in 95% alcohol or treat with commercially available spray fixative.
Forms
Useful For
Screening for cervical carcinoma and a number of infections of the female genital tract including human papillomavirus, herpes, Candida, and Trichomonas
Reflex Tests
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
CVSPC | Physician Interp Conventional | No | No |
Special Instructions
Method Name
Light Microscopy
Reporting Name
Conventional Smear-DiagnosticSpecimen Type
VariesSpecimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Varies | Ambient (preferred) | SLIDE | |
Refrigerated | SLIDE |
Reject Due To
SurePath vial | Reject |
Clinical Information
Squamous cell carcinoma of the cervix is believed to develop in progressive stages from normal through precancerous (dysplastic) stages, to carcinoma in situ, and eventually invasive carcinoma. This sequence is felt to develop over a matter of years in most patients.
The etiology of cervical carcinoma is unknown, but the disease is believed to be related to sexual activity and possibly sexually transmitted viral infections such as human papillomavirus (HPV).
Most cervical carcinomas and precancerous conditions occur in the transformation zone (squamo-columnar junction), therefore, this area needs to be sampled if optimum results are to be obtained.
Reference Values
Satisfactory for evaluation. Negative for intraepithelial lesion or malignancy.
Note: Abnormal results will be reviewed by a physician at an additional charge.
Interpretation
Standard reporting, as defined by the Bethesda System (TBS) is utilized.
Cautions
If endocervical cells have not been obtained (less than optimal smears) the results may be unreliable.
There is a false-negative rate of 10% to 20% in the presence of cervical intraepithelial neoplasia or invasive squamous cell carcinoma.
The Papanicolaou test is unreliable for endometrial carcinoma (at least 50% false-negative rate).
Day(s) Performed
Monday through Friday
Report Available
2 to 5 daysSpecimen Retention Time
5 yearsPerforming Laboratory
Mayo Clinic Laboratories in RochesterCPT Code Information
P3000
88164
88141-CVSPC (if appropriate)