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HelpEpic Test Code LAB101011 Acetylcholine Receptor Modulating Antibody
Additional Codes
Quest Code: 26474
Performing Location(s)
Quest
Specimen Type
Serum
Preferred Container
Red Top Tube or SST
Blood Tube Draw Volume
Min 50% draw volume
Minumum Volume to Submit for Testing
1 mL serum
Storage Requirements
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 30 days
Transportation Needs
Room Temperature
Causes of Rejection
Mislabeled or unlabeled specimen
Less than 50% draw for Vacutainer tubes
Gross hemolysis
Grossly lipemic
Microbially contaminated
Reference Range
<32 % Inhibition
Days of Analysis
Sunday and Wednesday
Maximum Laboratory Time
5 days
Additional Information
Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. AChR modulating antibodies cross-link AChR molecules on cell surface, promoting internalization, and decreasing AChR surface density. The AChR binding and modulating antibody assays have similar sensitivities, but performing them together increases sensitivity of antibody detection by approximately 5%
Limitations
Antibodies may not be found in congenital myasthenia
Methodology
Radiobinding Assay (RBA)
CPT Code
83519
Last Updated
5-Oct-18