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HelpEpic Test Code LAB101011 NeoEncephalitis Paraneoplastic Profile with Recombx
Additional Codes
Athena Code: 4722
Type of Disorder
Paraneoplastic and Other Antibody Disorders of the CNS
Disease(s) Tested for:
Paraneoplastic Neurological Syndrome, Autoimmune Encephalitis, Stiff Person Syndrome
Specimen Type
Serum
Preferred Container
Red Top
Minimum Volume
2 mL Serum
Specimen Stability
Room temperature: 72 hours
Refrigerated: 28 days
Frozen: 28 days
Transportation Needs
Refrigerated
Reference Values
See Laboratory Report
Includes
GAD65 Neurological Syndrome Antibody Test
NMDA Receptor (NR1-subunit) Autoantibody Test
Recombx® Amphiphysin Autoantibody Test
Recombx® CV2 Autoantibody Test
Test Turnaround
7-10 days
Clinical Significance
Anti-Hu, anti-CV2, anti-Ma, anti-Ta, anti-voltage gated potassium channels (VGKC), anti-Amphiphysin, anti-GAD65, anti-NMDA receptor (NR1-subunit), anti- LGI1, and anti-CASPR2 antibodies are found in patients with the acute or subacute onset of limbic encephalitis including confusion/dementia, depression/anxiety and/or seizures or hallucinations and usually MRI changes in medial temporal lobes. This semi-quantitative assay may be useful in monitoring therapeutic responses in select cases.
Methodology
Automated Nanoliter Scale Immunoassay, ELISA, Radioimmunoassay, Immunofluorescence Assay (IFA)
CPT Code
86341(1), 83520(4), 83519(1) 86255(3)
Last Updated
14-Feb-22