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HelpEpic Test Code LAB1032 Hemoglobin Stability, Blood
Additional Codes
MML Code: UNHB
LIS Code: HGBUS
NY State Approved
YesPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
Hb Stability, BMethod Name
Only orderable as part of a profile or as a reflex. For more information see:
-HAEV1 / Hemolytic Anemia Evaluation, Blood
-HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood
-THEV1 / Thalassemia and Hemoglobinopathy Evaluation, Blood and Serum
-REVE2 / Erythrocytosis Evaluation, Blood
-MEV1 / Methemoglobinemia Evaluation, Blood
Isopropanol and Heat Stability
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole Blood EDTA | Refrigerated | 7 days |
Specimen Required
Only orderable as part of a profile or as a reflex. For more information see:
-HAEV1 / Hemolytic Anemia Evaluation, Blood
-HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood
-THEV1 / Thalassemia and Hemoglobinopathy Evaluation, Blood and Serum
-REVE2 / Erythrocytosis Evaluation, Blood
-MEV1 / Methemoglobinemia Evaluation, Blood
Container/Tube: Lavender top (EDTA)
Specimen Volume: 4 mL
Specimen Type
Whole Blood EDTASpecimen Minimum Volume
1 mL
Reference Values
Only orderable as part of a profile or as a reflex. For more information see:
-HAEV1 / Hemolytic Anemia Evaluation, Blood
-HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood
-THEV1 / Thalassemia and Hemoglobinopathy Evaluation, Blood and Serum
-REVE2 / Erythrocytosis Evaluation, Blood
-MEV1 / Methemoglobinemia Evaluation, Blood
Normal (reported as normal [stable] or abnormal [unstable])
Report Available
1 to 4 daysDay(s) Performed
Monday through Friday
CPT Code Information
83068
Reject Due To
| Gross hemolysis | Reject |
Useful For
Work-up of congenital hemolytic anemias
Clinical Information
Unstable hemoglobin disease is rare and may be caused by any one of a large number of hemoglobin variants. They are inherited as autosomal dominant traits. The severity of the disease varies according to the hemoglobin variant; there may be no clinical symptoms, or the disease may produce a mild, moderate, or severe hemolytic anemia.
The stained peripheral blood smear shows anisocytosis, poikilocytosis, basophilic stippling, polychromasia and, sometimes, hypochromia. The reticulocyte count may be increased. Splenomegaly and Heinz bodies may also be present.
Interpretation
An abnormal or unstable result is indicative of a hemoglobin variant present. Other confirmatory tests should be performed to identify the hemoglobinopathy (HBEL1 / Hemoglobin Electrophoresis Cascade, Blood).
Cautions
False-positive results will be obtained in blood specimens containing greater than 5% fetal hemoglobin or in specimens greater than 1 week old.