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HelpEpic Test Code LAB105 Myoglobin, Serum
Additional Codes
MML Code: MYGLS
LIS Code: MYGB
NY State Approved
YesPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
Myoglobin, SMethod Name
Electrochemiluminescent Immunoassay (ECLIA)
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 365 days | ||
| Ambient | 7 days |
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial.
Specimen Type
SerumSpecimen Minimum Volume
0.6 mL
Reference Values
Males: 0 to 72 mcg/L
Females: 0 to 58 mcg/L
Report Available
1 to 2 daysDay(s) Performed
Monday through Sunday
CPT Code Information
83874
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Useful For
Assessing muscle damage from any cause
Clinical Information
Myoglobin is a heme protein found in smooth and skeletal muscles. Serum myoglobin reflects a balance between intravascular release of myoglobin from muscle and renal clearance.
Previously serum myoglobin had been advocated as a sensitive marker for early acute myocardial injury (eg, acute myocardial infarction: AMI). However, more recent studies indicate that newer markers (eg, troponin) provide superior diagnostic utility in detecting early myocardial injury.
Elevation of serum myoglobin may occur as a result of muscle trauma, resuscitation, myopathies, AMI, shock, strenuous body activity, or decreased elimination during renal insufficiency. Extreme elevations occur in rhabdomyolysis. Creatine kinase is released from muscle and used more commonly for this purpose.
Interpretation
Elevated myoglobin levels are seen in conditions of acute muscle injury.
Cautions
Elevation is nonspecific for acute myocardial infarction. The test is of no value in this regard in the presence of kidney failure, rhabdomyolysis, extensive trauma, acute peripheral vascular occlusion, or after seizures.
Serum levels rise in renal insufficiency.
In very rare cases, gammopathy, in particular type IgM (Waldenstrom macroglobulinemia), may cause unreliable results.