Home
HelpEpic Test Code LAB23 Digoxin
Performing Location(s)
BMC
Synonyms
Lanoxin
Specimen Type
Serum or Plasma
Preferred Container
Gold or Red top tube
Alternate Container
Green top tube
Blood Tube Draw Volume
Min 50% draw volume
Minimum Volume to Submit for Testing
0.5 mL Serum/Plasma
- Multiple test can be performed from this volume. For question please contact the lab at 547-3975.
Storage Requirements
Sample tubes should be centrifuged within 2 hour of collection followed by transfer of the serum (red or gold top) or plasma (green top) to a labeled plastic, aliquot tube.
See Causes of Rejection for temperature requirements.
Transportation Needs
Deliver specimen to laboratory within 1 hour of collection if unspun. If not possible see "storage Requirements".
Causes for Rejection
Mislabeled or unlabeled specimen
Less than 50% draw for Vacutainer tubes
> 7 days refrigerated
> 8 hours Room Tempature
> 6 months Frozen
Hemolysis > 800 mg/dL HgB
Lipemia > 1000 mg/dL Trig
Bilirubin > 30 mg/dL Bili
Citrate,NaF,Oxalate
Limitations
Endogenous, digoxin-like immunoreactive factors (DLIF) have been detected in the serum and plasma of neonates, pregnant women, and patients in renal and hepatic failure. Several studies have established that these factors can cause falsely elevated digoxin measurements when assayed by commercially available immunoassays.
Digoxin bound to Fab fragments of antidigoxin antibodies, as found in serum and plasma of individuals being treated for digoxin toxicity, may result in misleading digoxin values.
Patients taking biotin supplements in excess of the daily recommended allowance may cause falsely elevated results.
The following substances have been shown to cross-react with the DIGXN method:
| Substance | Digoxin Level Tested ng/mL [nmol/L] |
Cross Reactivity % |
| Acetyldigitoxin (25 ng/mL) | 0 [0] 2.00 [2.56] |
14 10 |
| Deslanoside (2.5 ng/mL) | 0 [0] 2.00 [2.56] |
56 63 |
| Digitoxin (25 ng/mL) | 0 [0] 2.00 [2.56] |
13 10 |
| Digoxigenin (5 ng/mL) | 0 [0] 2.00 [2.56] |
8 -9 |
| Digoxigenin bis-digitoxoside (2.5 ng/mL) | 0 [0] 2.00 [2.56] |
96 94 |
| Digoxigenin mono-digitoxoside (2.5 ng/mL) | 0 [0] 2.00 [2.56] |
59 52 |
| Dihydrodigoxin (25 ng/mL) | 0 [0] 2.00 [2.56] |
2 -3 |
| Gitoxin (25 ng/mL) | 0 [0] 2.00 [2.56] |
0 -1 |
| Lanatoside C (1.5 ng/mL) | 0 [0] 2.00 [2.56] |
59 70 |
Reference Values
| Population | Units | Therapeutic Range | High Critical Value |
| All populations | ng/mL | 0.8 - 2.0 | >2.4 |
Days of Analysis
All
Available STAT
Yes
Additional Information
Collection Guideline:
Monitor after patient reaches steady state and at least 8 hours after last dose. The serum concentration does not correlate with pharmacologic activity untli the post distribution period (at least 8-12 hours after last dose)
Includes
Quantitative analysis for Digoxin
Methodology
Beckman AU/Dx Series
CPT Code
80162
Last Updated
18-Mar-22 BHD