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HelpEpic Test Code LAB3193 ANA Screen with Reflex
Methodolgy
Fluorescence Enzyme Immunoassay (FEIA)
Specimen Required
Preferred: Serum Gel Acceptable: Red Top
Specimen Stability
Refrigerated
Specimen Type
Serum
Report Available
1-4 Days
Day(s) Performed
Mon-Thurs.
CPT Codes
ANA Screen with Reflex:
86038
86225
86235 × 8
ANA Screen without Reflex:
86038
86225
Reject Due To
Lipemic, hemolyzed or microbially contaminated samples may give poor results and should not be used. Undiluted samples at room temp > 8 hours.
Specimen Retention
Room Temp: 8 hours undiluted; Refrigerated: 14 days undiluted
Reference Values
ENA Screen (Symphony): <7 Negative 7-10 Equivocal >10 Positive dsDNA Antibodies: <10 Negative 10-15 Equivocal >15 Positive RNP70, Sm, Scl-70s, Jo-1, CENP, SSA/Ro, and SSA/La: <7 Negative 7-10 Equivocal >10 Positive U1RNP: <5 Negative 5-10 Equivocal >10 PositiveTesting Algorithm
The ANA screen interpretation si derived from a combination of the ENA screen and dsDNA results. If the ENA Screen (Symphony) is > 1.0, then antibodies to RNP 70, Sm, U1RNP, Scl-70s, Jo-1, CENP, SSA/Ro, and SSB/La are performed at an additional charge. There is no reflex testing available when only the dsDNA is elevated.
Limitations
A definitive clinical diagnosis should not be based on the results of a single diagnostic
method, but should only be made by the physician after all clinical and laboratory findings
have been evaluated.
In rare cases, interference due to extremely high titers of antibodies to streptavidin can
occur.