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Epic Test Code LAB3751 Butalbital, Serum

Additional Codes

MML Code: BUTAS

 

NY State Approved

Yes

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Reporting Name

Butalbital, S

Method Name

Gas Chromatography-Mass Spectrometry (GC-MS)

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (Serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1.5 mL

Collection Instructions:

1. Draw blood immediately before next scheduled dose.

2. Centrifuge and aliquot serum into a plastic vial within 2 hours of collection.


Bassett Healthcare Network Clinical Laboratories Note:

Blood Tube Draw Volume

Min 50% draw volume　　

Specimen Type

Serum Red

Specimen Minimum Volume

0.6 mL

Reference Values

Therapeutic concentration: <10 mcg/mL

Toxic concentration: ≥10 mcg/mL

Report Available

3 to 9 days

Day(s) Performed

Thursday

CPT Code Information

80299

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK

Useful For

Monitoring butalbital therapy

Clinical Information

Butalbital, a short-acting barbiturate with hypnotic properties, is used in combination with other drugs such as acetaminophen, salicylate, caffeine, and codeine.(1)

 

Butalbital is administered orally. The duration of its hypnotic effect is about 3 to 4 hours. The drug distributes throughout the body, with a volume of distribution of 0.8 L/kg, and about 26% of a dose is bound to plasma proteins. The half-life of butalbital is about 35 to 88 hours. Excretion occurs mainly in the urine.(1,2)

Interpretation

Butalbital concentrations of 10 mcg/mL or greater have been associated with toxicity.

Cautions

Specimens collected in serum gel tubes are not acceptable because the drug can absorb on the gel and lead to falsely decreased concentrations.

Specimen Retention Time

2 weeks

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.