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HelpEpic Test Code LAB3776 Granulocyte Antibodies, Serum
Additional Codes
MML Code: LAGGT
LIS Code : ANTA
NY State Approved
YesPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Reporting Name
Granulocyte Ab, SMethod Name
Indirect Immunofluorescence
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 30 days | |
| Frozen | 365 days | ||
| Ambient | 7 days |
Specimen Required
Collection Container/Tube: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Additional Information: Only pretransfusion reaction specimen is acceptable.
Specimen Type
Serum RedSpecimen Minimum Volume
0.3 mL
Reference Values
Not applicable
Report Available
7 to 15 daysDay(s) Performed
Tuesday, Wednesday, Friday
CPT Code Information
86021
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Useful For
Work-up of individuals having febrile, nonhemolytic transfusion reactions
Detection of individuals with autoimmune neutropenia
This test is not useful for the diagnosis of neutropenia caused by marrow suppression by drugs or tumors.
Clinical Information
Granulocyte antibodies are induced by pregnancy or prior transfusion and are associated with febrile, nonhemolytic transfusion reactions. Patients who have been immunized by previous transfusions, pregnancies, or allografts frequently experience febrile, nonhemolytic transfusion reactions that must be distinguished from hemolysis before further transfusions can be safely administered. Granulocyte antibodies may also be present in autoimmune neutropenia.
Interpretation
A positive result in an individual being worked up for a febrile transfusion reaction indicates the need for leukocyte-poor (filtered) red blood cells.
This test cannot distinguish between allo- and autoantibodies
Cautions
No significant cautionary statements