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HelpEpic Test Code LAB3832 PM/Scl-100 Antibody, IgG by Immunoblot
Additional Codes
ARUP: 2003040
Ordering Recommendation
May be useful when evaluating for systemic sclerosis or connective tissue disease associated with overlapping features of systemic sclerosis and/or myositis.
Specimen Type
Serum
Preferred Container
Serum separator tube
Volume Required
1 mL
Minimum Volume
0.3 mL
Transportation Needs
Transport Temperature: Refrigerated
Transfer 1 mL serum to an ARUP Standard Transport Tube.
Storage Requirements
After separation from cells:
Ambient: 48 hours
Refrigerated: 2 weeks
Frozen: 1 year
Cause of Rejection
Plasma.
Contaminated, hemolyzed, or severely lipemic specimens
Turnaround Time
1-4 days
Performed Tue, Thu, Sat
Methodology
Qualitative Immunoblot
Reference Value
Negative
Additional Information
The presence of PM/Scl-100 IgG antibody along with a positive ANA IFA nucleolar pattern is associated with connective tissue diseases such as polymyositis (PM), dermatomyositis (DM), systemic sclerosis (SSc), and polymyositis/systemic sclerosis overlap syndrome. The clinical relevance of PM/Scl-100 IgG antibody with a negative ANA IFA nucleolar pattern is unknown. PM/Scl-100 is the main target epitope of the PM/Scl complex, although antibodies to other targets not detected by this assay may occur.
CPT Code
86235
Last Updated
29-Jun-17