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HelpEpic Test Code LAB432 Cyclic Adenosine Monophosphate (cAMP), Urinary Excretion, Serum and Urine
Additional Codes
MML:CARU
Specimen Required
Both serum and urine are required. Serum must be obtained at the time of the urine collection.
Specimen Type: Serum
Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Serum gel tubes should be centrifuged within 2 hours of collection.
2. Red-top tubes should be centrifuged, and the serum aliquoted into a plastic vial within 2 hours of collection.
3. Label specimen as serum.
Specimen Type: Urine
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Container/Tube: Plastic vial
Specimen Volume: 5 mL
Collection Instructions:
1. Collect a random urine specimen.
2. Label specimen as urine.
Useful For
Differential diagnosis of hypercalcemia
As an adjunct to serum parathyroid hormone measurements, especially in the diagnosis of parathyroid hormone resistance states, such as pseudohypoparathyroidism
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ACREA | Creatinine, S | Yes, (order CRTS1) | Yes |
| CAMP | Cyclic Amp, Urinary Excretion | No | Yes |
| CRETR | Creatinine, Random, U | Yes, (order RCTUR) | Yes |
Method Name
ACREA, CRETR: Enzymatic Colorimetric Assay
CAMP: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Cyclic Amp, Urinary ExcretionSpecimen Type
SerumUrine
Specimen Minimum Volume
Serum: 0.5 mL
Urine: 2.0 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 7 days |
| Frozen | 90 days | |
| Urine | Refrigerated (preferred) | 28 days |
| Frozen | 28 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Clinical Information
Adenosine cyclic 3',5'-monophosphate (cAMP) functions as an intracellular "second messenger" regulating the activity of intracellular enzymes or proteins in response to a variety of hormones (eg, parathyroid hormone).
Urinary cAMP is elevated in about 85% of patients with hyperparathyroidism.
Reference Values
CYCLIC AMP
1.3-3.7 nmol/dL of glomerular filtrate
CREATININE, SERUM
Males
0-11 months: 0.17-0.42 mg/dL
1-5 years: 0.19-0.49 mg/dL
6-10 years: 0.26-0.61 mg/dL
11-14 years: 0.35-0.86 mg/dL
≥15 years: 0.74-1.35 mg/dL
Females
0-11 months: 0.17-0.42 mg/dL
1-5 years: 0.19-0.49 mg/dL
6-10 years: 0.26-0.61 mg/dL
11-15 years: 0.35-0.86 mg/dL
≥16 years: 0.59-1.04 mg/dL
CREATININE, URINE
No reference values apply. Interpret with other clinical data.
Interpretation
Urinary adenosine cyclic 3',5'-monophosphate (cAMP) is elevated in about 85% of patients with hyperparathyroidism and in about 50% of patients with humoral hypercalcemia of malignancy.
Cautions
Parathyroid suppression (hypoparathyroidism) does not lower urinary adenosine cyclic 3',5'-monophosphate (cAMP) excretion to definitively subnormal values.
Day(s) Performed
Wednesday
Report Available
2 to 10 daysSpecimen Retention Time
14 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82030
82570
82565