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Epic Test Code LAB84 Zinc Protoporphyrin (ZPP), Whole Blood

Additional Codes

ARUP:0020605

Alternate for LAB1085

Ordering Recommendation

May be useful as an indicator of lead exposure; not recommended as the primary screening test for lead exposure. For lead exposure assessment, Lead Blood (Venous) (0020098) is preferred. For iron deficiency assessment, Iron and Iron Binding Capacity (0020420) and Ferritin (0070065) are recommended. For assessment of occupational exposure to lead, Lead Industrial Exposure Panel, Adults (0025016) is recommended.

Specimen Type

Whole Blood

Collection Container

Lavender (EDTA); Royal blue, (EDTA), tan (EDTA), or pink (K2 EDTA).

Minumum Volume to Submit for Testing

1 mL whole blood. (Min: 0.2 mL)

Storage Requirements

Ambient: 30 hours
Refrigerated: 5 weeks
Frozen: Unacceptable

Transportation Needs

Refrigerated

Cause of Rejection

Mislabled or unlabeled

Specimens not collected in EDTA. Clotted, frozen, or hemolyzed specimens.

Reference Value

0-69 µmol ZPP/ mol Hem

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Elevated ZPP results are seen in early and late iron deficiency, the anemia of chronic disease, chronic lead poisoning, and erythropoietic protoporphyria.  Elevated bilirubin or riboflavin and hemolyzed, clotted, or improperly aliquoted specimens may falsely increase the ZPP concentration.


A more specific test for free protoporphyrin is Porphyrins, Serum Total (0080429).  Erythrocyte Porphyrin (EP), Whole Blood (0020610), measures free protoporphyrin and zinc protoporphyrin.

Turnaround Time

1-4 days

Days Performed

Mon-Fri

Methodology

Quantitative Hematofluorometry

CPT Code

84202

Last Updated

5-Oct-21