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Epic Test Code LAB869 HLA-B27, Blood

Additional Codes

MML Code: LY27B

LIS Code: HB27

NY State Approved

Yes

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Reporting Name

HLA-B27, B

Method Name

Flow Cytometry

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood EDTA Ambient 4 days


Ordering Guidance


This test is best used alone if a particular disease, such as ankylosing spondylitis, is under consideration.

 

Orders received for both this test and 1LRR / Human Leukocyte Antigens (HLA) Class I Typing Low Resolution, Recipient, Blood or 1DIS / Human Leukocyte Antigens (HLA) A-B-C Disease Association Typing Low Resolution, Blood (which provides data on all HLA Class I low-resolution antigens, including B27) will be questioned due to test overlap.



Shipping Instructions


Specimen must arrive within 96 hours of collection.



Specimen Required


Container/Tube: Lavender top (EDTA)

Specimen Volume: 6 mL

Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.


Specimen Type

Whole Blood EDTA

Specimen Minimum Volume

1 mL

Reference Values

An interpretive report will be provided.

Report Available

2 to 6 days

Day(s) Performed

Monday through Saturday

CPT Code Information

86812

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Useful For

Assisting in the diagnostic process of ankylosing spondylitis, juvenile rheumatoid arthritis, and reactive arthritis

Clinical Information

This major histocompatibility coded class I antigen is associated with ankylosing spondylitis, juvenile rheumatoid arthritis, and reactive arthritis. The mechanism of the association is not understood but probably is that of linkage disequilibrium.

 

There is an increased prevalence of human leukocyte antigen (HLA)-B27 in certain rheumatic diseases, particularly ankylosing spondylitis.

 

Studies have demonstrated that the HLA-B*27:06 allele, which is present in a small percentage of individuals of Asian ethnicity, may not be associated with ankylosing spondylitis.

Interpretation

Approximately 8% of the normal population carries the human leukocyte antigen (HLA)-B27.

 

HLA-B27 is present in approximately 89% of patients with ankylosing spondylitis, 79% of patients with reactive arthritis, and 42% of patients with juvenile rheumatoid arthritis. However, lacking other data, it is not diagnostic for these disorders.

Cautions

Extreme temperature changes during shipping may alter the specimen making it unacceptable for testing.

Specimen Retention Time

7 days

Forms

If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.