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HelpEpic Test Code MITAN Mitotane, Plasma
Shipping Instructions
Ship specimen refrigerated.
Specimen Required
Collection Container/Tube: Green top (sodium heparin) (Lithium heparin and PST/plasma gel tubes are not acceptable.)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Within 2 hours of collection, centrifuge and aliquot plasma into plastic vial.
Useful For
Assessing compliance or making dosage adjustments for mitotane
Method Name
Gas Chromatography Mass Spectrometry (GC-MS) Confirmation with Quantitation
Reporting Name
Mitotane, PSpecimen Type
Plasma Na HeparinSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Plasma Na Heparin | Refrigerated (preferred) | 21 days |
| Frozen | 28 days | |
| Ambient | 72 hours |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | Reject |
| Gross icterus | OK |
Clinical Information
This test is intended for the use of therapeutic monitoring of the drug mitotane in patients being treated for adrenal carcinoma. Guidelines suggest monitoring mitotane serum/plasma levels every 2 to 3 weeks for the first 3 months. After reaching a plateau, the interval can be extended (eg, every 6 weeks). Mitotane is a key drug for the treatment of adrenal cortical carcinoma. Due to its narrow therapeutic window (14 to 20 mcg/mL), monitoring its concentration is crucially important.
Reference Values
Therapeutic: 14-20 mcg/mL
Interpretation
In the literature when mitotane is used to treat adrenocortical carcinoma, the maximum benefit is seen when plasma mitotane concentrations are between 14-20 mcg/mL.
Cautions
No significant cautionary statements
Day(s) Performed
Tuesday, Thursday
Report Available
2 to 7 daysSpecimen Retention Time
14 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
80299
NY State Approved
YesForms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.